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Bone mass loss and vitamin D metabolism impairment in HIV patients receiving highly active antiretroviral therapy

Madeddu, Giordano and Spanu, Angela and Solinas, Patrizia and Calia, Giovanna Maria and Lovigu, Carla and Chessa, Francesca and Mannazzu, Ilaria Maria and Falchi, Antonio and Mura, Maria Stella Anna and Madeddu, Giuseppe (2004) Bone mass loss and vitamin D metabolism impairment in HIV patients receiving highly active antiretroviral therapy. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 48 (1), p. 39-48. eISSN 1827-1936. Article.

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AIM: Given the few controversial data about the effect of highly active antiretroviral therapy (HAART) on bone mass in HIV patients, we investigated whether a relationship between osteopenia/osteoporosis risk and HAART exists. METHODS: In 172 HIV patients, 152 on HAART, 92 including and 60 not including protease inhibitors (PI), 20 naïve and 64 controls, we measured spine/femur bone mineral density (BMD) by DEXA, and assayed serum osteocalcin (O), bone alkaline phosphatase (BAP), 1,25(OH)2 D, parathormone (PTH), calcium (Ca) and urinary pyridinium cross-links (PYD &DPD). RESULTS: Following WHO BMD t-score criteria, osteopenia was ascertained in >35% of all HAART groups and in 30% of naive. Only HAART patients had osteoporosis, PI patients more frequently, significantly (p<0.03) in spine (21.7% vs 8.3%). Males, intravenous drug users and B-C stage patients have a higher risk for low bone mass. Mean t-score was significantly lower in both spine and femur and O and PYD & DPD higher in PI than non PI patients and controls; 1,25(OH)2 D was significantly lower in all HIV groups than controls, PI patients having the lowest values positively correlating with BMD and negatively with OC and PYD & DPD, and it decreased further in 27 non selected monitored patients continuing on HAART. PTH was higher and Ca lower in HAART patients than controls but not significantly, PTH negatively correlating with BMD. CONCLUSION: HAART could be associated with osteopenia, even osteoporosis, and it could aggravate the loss in bone mass due to HIV infection itself. We hypothesize that HAART may directly affect bone remodelling and/or may indirectly affect vitamin D metabolism.

Item Type:Article
ID Code:258
Uncontrolled Keywords:Highly active antiretroviral therapy, metabolic bone diseases, osteoporosis, bone density, bone remodelling markers, vitamin D
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 06 - Scienze mediche > MED/17 Malattie infettive
Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Area 07 - Scienze agrarie e veterinarie > AGR/16 Microbiologia agraria
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
001 Università di Sassari > 01 Dipartimenti > Scienze ambientali agrarie e biotecnologie agro-alimentari
Publisher:Edizioni Minerva Medica
Deposited On:18 Aug 2009 10:01

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