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3,6-diazabicyclos[3.1.1]heptane derivatives with analgesic activity

Pinna, Gérard Aimé and Loriga, Giovanni and Cignarella, Giorgio (2005) 3,6-diazabicyclos[3.1.1]heptane derivatives with analgesic activity. WO/2005/108402. Patent.

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Abstract

The invention relates to compounds of general formula (I), wherein R and R1, different from one another, are: a C2-C8 straight or branched acyl group; and a group of formula (II), wherein B and R2 are as defined in the description. The compounds (I) have higher central analgesic activity than morphine and are substantially free from the side effects of morphine or other central analgesics. The invention further relates to a process for the preparation of the compounds (I).

Item Type:Patent
ID Code:2560
Status:Published
Uncontrolled Keywords:Heptane derivatives, analgesic activity
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Patent Applicant:Università degli studi di Milano, Università degli studi di Sassari, Gérard Aimé Pinna, Giovanni Loriga, Giorgio Cignarella
International Application Number:WO2005EP04994 20050509, PCT/EP2005/004994
International Patent Classification:A61K31/4995; C07D487/00; (IPC1-7): C07D487/08; A61P25/04
Attorney, Agent, or Firm:Bianchetti, Giuseppe
Deposited On:18 Aug 2009 10:08

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