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Advances in chemical synthesis of carbasugars and analogues

Rassu, Gloria Maria Rita and Auzzas, Luciana and Pinna, Luigi and Battistini, Lucia and Curti, Laudio (2003) Advances in chemical synthesis of carbasugars and analogues. Studies in Natural Products Chemistry, Vol. 29 (Part 10), p. 449-520. ISSN 1572-5995. Article.

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DOI: 10.1016/S1572-5995(03)80013-3

Abstract

Carbasugars, carbocyclic structures where a carbon atom — usually a methylene — replaces oxygen in the heterocyclic motif of the carbohydrates, represent an important class of natural and synthetic compounds that exhibit far-reaching biological effects. In this article the carbasugars have been divided into three main categories, those embodying a cyclopentane motif (furanoid carbasugars), those incorporating a cyclohexane motif (pyranoid carbasugars), and those bearing rather rare cyclopropane, cyclobutane, cycloheptane, and cyclooctane cores (contracted and expanded carbasugars).

In the three major sections of this article, the most representative syntheses of the carbasugars and their closest analogues are analyzed, and the key carboc forming manoeuvres are focused on in particular detail. Reference to the observed biological activity is also included, where sufficient data is available. Only recent literature from the 90s onwards was considered, although the most pioneer works on this matter have also been remembered.

Lack of space did not permit us to cover this field completely; however, in order to offer the reader a wider coverage of this subject matter, two tables listing important review articles and papers dealing with carbasugars, not discussed in the text, have been included in the final section of this account.

Item Type:Article
ID Code:2541
Status:Published
Refereed:Yes
Uncontrolled Keywords:Carbasugars, carbocyclic structures
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Elsevier
ISSN:1572-5995
Deposited On:18 Aug 2009 10:08

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