Alkali metal-mediated synthesis of 1- and 4-substituted N-Alkyl-1,2,3,4-tetrahydroisoquinolines

Azzena, Ugo Gavino and Pisano, Luisa and Pittalis, Mario (2004) Alkali metal-mediated synthesis of 1- and 4-substituted N-Alkyl-1,2,3,4-tetrahydroisoquinolines. Heterocycles, Vol. 63 (2), p. 401-409. ISSN 0385-5414. Article.

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DOI: 10.3987/COM-03-9936

Abstract

Reductive cleavage by electron transfer from Li or K metal of 1-alkoxy-substituted N-alkyltetrahydroisoquinolines led to the formation of organometallic derivatives. Quenching of these intermediates with electrophilic reagents afforded 1- or 4-substituted N-alkyl-1,2,3,4-tetrahydroisoquinolines, depending upon the nature of the metal.

Item Type:	Article
ID Code:	2536
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Isoquinoline derivatives
Subjects:	Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:	Elsevier
ISSN:	0385-5414
Copyright Holders:	Copyright © 2004 The Japan Institute of Heterocyclic Chemistry
Deposited On:	18 Aug 2009 10:08

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