Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations

Masala, Maria Vittoria and Carcassi, Carlo and Cottoni, Francesca Maria Giovanna and Mulargia, Marina and Contu, Licinio and Cerimele, Decio (2005) Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations. International Journal of Dermatology, Vol. 44 (9), p. 743-745. eISSN 1365-4632. Article.

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DOI: 10.1111/j.1365-4632.2004.02206.x

Abstract

Background
The incidence of classic Kaposi’s sarcoma (CKS) in northern Sardinia is one of the highest in the world.
Methods
Sixty-two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia.
Results
In the Sardinian patients, we observed a positive CKS association with Cw7, DRB1^*1104, DRB1^*1302, DQA1^*0302, and DQB1^*0604, and a negative CKS association with A30, B58, Cw5, DRB1^*1601, and DQB1^*0502.
Conclusions
The strong positive CKS association with DRB1^*1104 and DQB1^*0604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.

Item Type:	Article
ID Code:	2499
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	CKS, HLA molecules, Sardinia
Subjects:	Area 06 - Scienze mediche > MED/35 Malattie cutanee e veneree
Divisions:	001 Università di Sassari > 03 Istituti > Dermatologia
Publisher:	Blackwell / Wiley
eISSN:	1365-4632
Copyright Holders:	© 2004 The International Society of Dermatology
Deposited On:	18 Aug 2009 10:07

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