Masala, Maria Vittoria and Carcassi, Carlo and Cottoni, Francesca Maria Giovanna and Mulargia, Marina and Contu, Licinio and Cerimele, Decio (2005) Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations. International Journal of Dermatology, Vol. 44 (9), p. 743-745. eISSN 1365-4632. Article.
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The incidence of classic Kaposi’s sarcoma (CKS) in northern Sardinia is one of
the highest in the world.
Sixty-two patients with CKS were typed for class I and class II antigens. All patients
had been born and were living in northern Sardinia.
In the Sardinian patients, we observed a positive CKS association with Cw7,
DRB1*1104, DRB1*1302, DQA1*0302, and DQB1*0604, and a negative CKS association
with A30, B58, Cw5, DRB1*1601, and DQB1*0502.
The strong positive CKS association with DRB1*1104 and DQB1*0604 and
negative association with B58 are particularly significant and further support the notion of a
genetic predisposition to CKS.
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