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Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects

Quertemont, Etienne and Eriksson, C J. Peter and Zimatkin, Sergey M. and Pronko, Pavel S. and Diana, Marco and Pisano, Milena and Rodd, Zachary A. and Bell, Richard R. and Ward, Roberta J. (2005) Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects. Alcoholism: Clinical and Experimental Research, Vol. 29 (8), p. 1514-1521. eISSN 1530-0277. Article.

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DOI: 10.1097/01.alc.0000175015.51329.45

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Abstract

This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.

Item Type:Article
ID Code:2493
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acetaldehyde, ethanol, brain, catalase, self-administration, dopamine
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Lippincott Williams & Wilkins
eISSN:1530-0277
Copyright Holders:© 2005 by the Research Society on Alcoholism
Deposited On:18 Aug 2009 10:07

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