Enantioselective synthesis of (S)- and (R)-tolterodine by asymmetric hydrogenation of a coumarin derivative obtained by a Heck reaction

Ulgheri, Fausta and Marchetti, Mauro and Piccolo, Oreste (2007) Enantioselective synthesis of (S)- and (R)-tolterodine by asymmetric hydrogenation of a coumarin derivative obtained by a Heck reaction. The Journal of Organic Chemistry, Vol. 72 (16), p. 6056-6059. eISSN 1520-6904. Article.

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DOI: 10.1021/jo0705667

Abstract

An efficient and short enantioselective synthesis of (S)- and (R)-tolterodine was performed by asymmetric hydrogenation of a coumarin intermediate, easily obtained by a Heck reaction from inexpensive and commercially available starting materials.

Item Type:	Article
ID Code:	2476
Uncontrolled Keywords:	R-tol, S-tol, Heck reaction
Subjects:	Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:	002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:	American Chemical Society
eISSN:	1520-6904
Deposited On:	18 Aug 2009 10:07

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