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Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection

Sali, Michela and Delogu, Giovanni and Greco, Emanuela and Rocca, Stefano and Colizzi, Vittorio and Fadda, Giovanni and Fraziano, Maurizio (2009) Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection. International Journal of Immunopathology and Pharmacology, Vol. 22 (1), p. 175-181. ISSN 0394-6320. Article.

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Abstract

Sphingosine 1-phosphate (S1P) is a natural lysophospholipid able to enhance antimycobacterial innate immune response. In the present study, we address the possible therapeutic role of S1P administered during primary or acute infection in mice aerogenically infected with Mycobacterium tuberculosis (MTB). Results show that the administration of S1P during primary infection significantly reduces the presence of MTB-infected cells within pulmonary granulomas and mycobacterial burden in the lung and in the spleen. However, if S1P treatment was started during acute infection, a detrimental effect was observed in terms of pulmonary histopathology and mycobacterial burden in the lung and in the spleen. Taken together, these results show that S1P can exert a therapeutic effect as a treatment of primary infection only.

Item Type:Article
ID Code:2474
Status:Published
Refereed:Yes
Uncontrolled Keywords:S1P treatment, immune response, primary infection
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
Publisher:Biolife
ISSN:0394-6320
Deposited On:18 Aug 2009 10:07

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