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Twice-a-day quadruple therapy for eradication of Helicobacter pylori in the elderly

Dore, Maria Pina and Maragkoudakis, Emmanouil and Pironti, Antonella and Tadeu, Vincenza and Tedde, Rinaldo and Realdi, Giuseppe and Delitala, Giuseppe (2006) Twice-a-day quadruple therapy for eradication of Helicobacter pylori in the elderly. Helicobacter, Vol. 11 (1), p. 52-55. eISSN 1523-5378. Article.

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DOI: 10.1111/j.0083-8703.2006.00370.x

Abstract

Background: Midday and evening twice-a-day quadruple therapy appears to be the most effective therapy for Helicobacter pylori infection in Northern Sardinia, a site where antibiotics resistance is common. Aim: The objective of our study was to estimate the efficacy, side-effects, and compliance of a quadruple therapy containing esomeprazole in a group of dyspeptic elderly patients. Patients and Methods: Consecutive elderly patients positive for H. pylori infection and not previously treated for eradication were enrolled. Therapy consisted of esomeprazole 20 mg, tetracycline 500 mg, metronidazole 500 mg, and bismuth subcitrate tablets 240 mg, all twice-a-day with the midday and evening meals, for 10 days. Efficacy was evaluated using 13C-urea breath testing. Compliance was assessed after completing treatment and at follow up. Side effects were graded based on daily activities. Results: Ninety-five dyspeptic patients (range 65–81 years), 52 men and 43 women, were enrolled. The intention-to-treat cure rate was 91% (81 of 89; 95% CI = 88–99%) and, 95% (81 of 85; 95% CI = 83–96%) per-protocol analysis. Compliance was excellent. Mild-moderate side effects occurred in 27 patients. Conclusions: Esomeprazole containing quadruple therapy was highly successful for initial eradication of H. pylori in elderly patients.

Item Type:Article
ID Code:2473
Status:Published
Refereed:Yes
Uncontrolled Keywords:H. pylori in elderly, metronidazole, quadruple therapy, bismuth, tetracycline
Subjects:Area 06 - Scienze mediche > MED/12 Gastroenterologia
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
Publisher:Blackwell / Wiley
eISSN:1523-5378
Copyright Holders:© 2006 The Authors, Journal compilation © 2006 Blackwell
Deposited On:18 Aug 2009 10:07

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