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A Facile approach to the synthesis of chiral 2-substituted benzofurans

De Luca, Lidia Vera Giovanna and Giacomelli, Giampaolo and Nieddu, Giammario (2007) A Facile approach to the synthesis of chiral 2-substituted benzofurans. The Journal of Organic Chemistry, Vol. 72 (10), p. 3955-3957. eISSN 1520-6904. Article.

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DOI: 10.1021/jo070142c


An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of α-alkyl-2-benzofuranmethanamines from N-protected α-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.

Item Type:Article
ID Code:2466
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:American Chemical Society
Deposited On:18 Aug 2009 10:07

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