Chelucci, Giorgio Adolfo and Capitta, Francesca and Baldino, Salvatore and Pinna, Gérard Aimé (2007) One-Pot conversion of 1,1-dibromoalkenes into internal alkynes by sequential Suzuki - Miyaura and dehydrobromination reactions. Tetrahedron Letters, Vol. 48 (37), p. 6514-6517. ISSN 0040-4039. Article.
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A protocol for the one-pot synthesis of internal alkynes from 1,1-dibromoalkenes is reported. The method is hinged upon the Suzuki–Miyaura cross-coupling of 2-aryl- or 2-heteroaryl-1,1-dibromoalkenes with aryl or heteroaryl boronic acids or borate esters followed by dehydrobromination of the intermediate coupled products. Yields up to 89% were obtained.
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