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In vitro antimycotic activity of some plant extracts towards yeast and yeast-like strains

Turchetti, Benedetta and Pinelli, Patrizia and Buzzini, Pietro and Romani, Annalisa and Heimler, Daniela and Franconi, Flavia and Martini, Alessandro (2005) In vitro antimycotic activity of some plant extracts towards yeast and yeast-like strains. Phytotherapy Research, Vol. 19 (1), p. 44-49. eISSN 1099-1573. Article.

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DOI: 10.1002/ptr.1622


As part of screening aimed at the selection of novel antimycotic compounds of vegetable origin, leaf extracts of Camellia sinensis L., Cupressus sempervirens L. and Pistacia lentiscus L. and the seed extract of Glycine soja Sieb. et Zucc. were tested against yeast and yeast-like species implicated in human mycoses. Of the extracts only those of C. sinensis (obtained from a commercial preparation of green tea) exhibited broad activity towards Candida glabrata, Clavispora lusitatiae, Cryptococcus laurentii, Filobasidiella neoformans, Issatchenkia orientalis, Saccharomyces cerevisiae and Prototheca wickerhamii strains. MICs ranging from 300 to 4800 µg extract[sol ]mL (corresponding to 130-2010 µg[sol ]mL total polyphenols) were observed. Concentrations of the C. sinensis extract over 25 000 µg[sol ]mL caused a rapid decrease of viable cells of Fil. neoformans and its activity was dose-dependent. Tests carried out using the pure polyphenols present in C. sinensis extract composition, showed that only epicatechin-3-O-gallate (ECG) and epigallocatechin-3-O-gallate (EGCG) possess antimycotic activity.

Item Type:Article
ID Code:2449
Uncontrolled Keywords:Antimycotic activity, Camellia sinensis L, yeast and yeast-like strains, ECG, EGCG
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Deposited On:18 Aug 2009 10:07

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