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Abnormal eye movements predict disability in MS: two-year follow-up

Derwenskus, Joy and Rucker, Janet C. and Serra, Alessandro and Stahl, John S. and Downey, Deborah L. and Adams, Nancy L. and Leigh, R. John (2005) Abnormal eye movements predict disability in MS: two-year follow-up. Annals of the New York Academy of Sciences, Vol. 1039 (Clinical and basic oculomotor research in honor of David S. Zee), p. 521-523. eISSN 1749-6632. Article.

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DOI: 10.1196/annals.1325.058


We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly ( p < .001 ) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.

Item Type:Article
ID Code:2446
Uncontrolled Keywords:Internuclear ophthalmoplegia, saccadic dysmetria, nystagmus
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:Blackwell / Wiley
Copyright Holders:© 2005 New York Academy of Sciences
Deposited On:18 Aug 2009 10:07

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