Derwenskus, Joy and Rucker, Janet C. and Serra, Alessandro and Stahl, John S. and Downey, Deborah L. and Adams, Nancy L. and Leigh, R. John (2005) Abnormal eye movements predict disability in MS: two-year follow-up. Annals of the New York Academy of Sciences, Vol. 1039 (Clinical and basic oculomotor research in honor of David S. Zee), p. 521-523. eISSN 1749-6632. Article.
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We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly ( p < .001 ) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.
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