UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACPI and sex

Bottini, Nunzio and Meloni, Gianfranco and Lucarelli, Paola and Amante, A. and Saccucci, Patrizia and Gloria-Bottini, Fulvia and Bottini, Egidio (2004) Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACPI and sex. Diabetes/Metabolism Research and Reviews, Vol. 21 , p. 353-358. eISSN 1520-7560. Article.

Full text not available from this repository.

DOI: 10.1002/dmrr.521

Abstract

Background We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery and risk of type 1 diabetes in the offspring. Methods One hundred and eighty-nine consecutive children with type 1 diabetes (TIDM) diagnosed at the Department of Pediatrics of the University of Sassari (Sardinia) were studied. A control sample of 5460 consecutive newborns from the same population was also studied. Results Maternal age at birth of children with type 1 diabetes has shifted towards high values. There is also an effect of birth order on the susceptibility to type 1 diabetes, which is independent of that due to maternal age. The proportion of low activity ACPl genotypes is much higher among children born from older mothers than among diabetic children born from relatively young mothers. There is a significant effect of sex, maternal age, sex-ACPl two-way interaction and sex-ACP1-maternal age three-way interaction on the age at diagnosis of diabetes. Conclusions The present data confirm the strong association between maternal age at delivery and risk of type 1 diabetes in the child. In addition, our analysis suggests a complex interaction among maternal age, sex of infant and ACP1 concerning age at diagnosis of diabetes. Thus, risk and clinical course of type 1 diabetes seem to be dependent on both maternal environment during intrauterine development and foetal genetic factors.

Item Type:Article
ID Code:2380
Status:Published
Refereed:Yes
Uncontrolled Keywords:Type 1 diabetes, maternal age, sex, ACP1
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Wiley
eISSN:1520-7560
Deposited On:18 Aug 2009 10:07

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page