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Inflammatory biomarkers in blood of patients with acute brain ischemia

Sotgiu, Stefano and Zanda, Bastianina and Marchetti, Bianca Maria and Fois, Maria Laura and Arru, Giannina and Pes, Giovanni Mario and Salaris, F. S. and Arru, A. and Pirisi, A. and Rosati, Giulio (2006) Inflammatory biomarkers in blood of patients with acute brain ischemia. European Journal of Neurology, Vol. 13 (5), p. 505-513. eISSN 1468-1331. Article.

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DOI: 10.1111/j.1468-1331.2006.01280.x

Abstract

Although many failed surrogate markers are provided in the literature, inflammation may contribute to the outcome of ischemic stroke. In 50 consecutive patients with acute ischemic stroke, in the absence of symptoms and signs of concomitant infection, we evaluated a panel of biomarkers reported to be variably associated with brain ischemia, and correlate their serum level with the brain lesion volume and clinical outcome. Infarct size was calculated on computed tomography (CT) scans by means of the Cavalieri's method. Neurological impairment was scored by using the Glasgow Coma Scale, Glasgow Outcome Scale and National Institutes of Health (NIH) scales at stroke onset and 3-month follow-up. Some markers showed a direct significant correlation with both initial and final NIH scale and with infarct size, particularly tumor necrosis factor alpha (TNF-α) (P = 0.002), intercellular adhesion molecule-1 (P < 0.01) and matrix metalloproteinase-2/9 (P = 0.001). In contrast to previous reports, interleukin-6 (IL-6) serum level showed a significant inverse correlation with both final neurological impairment and infarct size (P < 0.001). This novel finding allows us suggesting that IL-6, in the context of a complex pro-inflammatory network occurring during stroke, is associated with neuroprotection rather than neurotoxicity in patients with ischemic brain injury.

Item Type:Article
ID Code:2376
Status:Published
Refereed:Yes
Uncontrolled Keywords:Infarct size, interleukin-6, ischemic stroke, outcome, tumor necrosis factor
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Blackwell / Wiley
eISSN:1468-1331
Copyright Holders:© 2006 EFNS
Deposited On:18 Aug 2009 10:07

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