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Are the available experimental models of type 2 diabetes appropriate for a gender perspective?

Franconi, Flavia and Seghieri, Giuseppe and Canu, Silvia and Straface, Elisabetta and Campesi, Ilaria and Malorni, Walter (2008) Are the available experimental models of type 2 diabetes appropriate for a gender perspective? Pharmacological Research, Vol. 57 (1), p. 6-18. ISSN 1043-6618. Article.

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DOI: 10.1016/j.phrs.2007.11.007

Abstract

Several experimental models have so far been developed to improve our knowledge of the pathogenetic mechanisms of type 2 diabetes mellitus (T2D), to determine the possible pharmacological targets of this disease and to better evaluate diabetes-associated complications, e.g. the cardiovascular disease. In particular, the study of T2D gained the attention of several groups working with different animal species: rodents, cats or pigs, as well as other non-human primate species. Each of these species provided useful and different clues. However, T2D has to be considered as a gender-associated disease: sex differences play in fact a key role in the onset as well as in the progression of the disease and a higher mortality for cardiovascular diseases is detected in diabetic women with respect to men. The results obtained from all the available animal models appear to only partially address this issue so that the search for more precise information in this respect appears to be mandatory. In this review we summarize these concepts and literature in the field and propose a reappraisal of the various animal models for a study of T2D that would take into consideration a gender perspective.

Item Type:Article
ID Code:2053
Status:Published
Refereed:Yes
Uncontrolled Keywords:Diabetes mellitus, animal experimental models, gender, sex
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Elsevier
ISSN:1043-6618
Copyright Holders:© 2007 Elsevier
Deposited On:18 Aug 2009 10:06

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