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Abacavir has a negative impact on rapid virologic response to pegylated interferon and ribavirrin combination treatment of hepatitis C in HIV-1 coinfected patients

Puoti, Massimo and Sacchi, Paolo and Nasta, Paola and Cariti, Giuseppe and Maida, Ivana Rita and Ladisa, Nicoletta and De Bona, Anna and Iannacone, C. and Di Perri, Giovanni and Toti, Mario and Bruno, Raffaele (2008) Abacavir has a negative impact on rapid virologic response to pegylated interferon and ribavirrin combination treatment of hepatitis C in HIV-1 coinfected patients. Journal of Hepatology, Vol. 48 (Suppl. 2), S309. ISSN 0168-8278. Article.

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DOI: 10.1016/S0168-8278(08)60826-0

Abstract

Ribavirin use and higher ribavirin doses are associated with accelerated viral decay during the very early phase of ant-HCV therapy. An interference of abacavir with ribavirin intracellular phosphorilation has been hypothesized. Thus, concurrent abacavir use should impair the early phases of viral decay during anti HCV treatment. A negative interaction seem to be confirmed by preliminary data from retrospective studies showing a negative impact of abacavir use on the sustained response to pegylated interferon and ribavirin combination treatment in HIV infected patients with chronic hepatitis C. However this association could be biased by confounders and not due to a reduced potency of anti HCV treatment.

Item Type:Article
ID Code:2047
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ribavirin, abacavir, anti HCV treatment
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:Elsevier Ireland
ISSN:0168-8278
Copyright Holders:© 2008 European Association for the Study of the Liver
Additional Information:Abstracts from the 43. Annual meeting of the European association for the study of the liver, Milan, Italy, 23-27 April 2008.
Deposited On:18 Aug 2009 10:06

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