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Prevalence of lactase persistence and the performance of a new non invasive genetic test in adult patients

Dore, Maria Pina and Pedroni, Antonietta and Peltonen, Leena and Enattah, Nabil Satri and Tadeu, Vincenza and Delitala, Giuseppe and Cavalli-Sforza, Luca and Obinu, Domenica Anna (2008) Prevalence of lactase persistence and the performance of a new non invasive genetic test in adult patients. Digestive and Liver Disease, Vol. 40 (Suppl. 1), S63. ISSN 1590-8658. Article.

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DOI: 10.1016/S1590-8658(08)60163-2

Abstract

Lactose malabsorption is a common problem in humans. Although not in all subjects lactose intake might cause diarrhea, abdominal pain, and flatulence limiting consumption of dairy products. The underlying mechanism of production of enzymes metabolizing lactose is genetically regulated. Persistent lactase activity was observed in populations that consumed milk products into adulthood. Genome polymorphisms are associated with persistence of lactase expression. The breath hydrogen test (BHT) is currently used to measure lactose nonabsorption, however false results can occur. Aim: To evaluate the prevalence of lactase persistence and the performance of a new non invasive genetic test based on the presence of C/T-13910 single nucleotide polymorphism.

Item Type:Article
ID Code:2035
Status:Published
Refereed:Yes
Uncontrolled Keywords:Lactose malabsorption, breath hydrogen test (BHT), C/T-13910 (homozygous genotype for lactase non-persistence), Sardinia
Subjects:Area 06 - Scienze mediche > MED/12 Gastroenterologia
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
002 Altri enti e centri di ricerca del Nord Sardegna > BGT Italia, Porto Torres
Publisher:Saunders / Elsevier
ISSN:1590-8658
Copyright Holders:© 2008 Editrice Gastroenterologica Italiana
Additional Information:Abstracts from the 14. National congress of digestive diseases - Italian Federation of Digestive Diseases, Rimini, Italy, 8-12 March 2008.
Deposited On:18 Aug 2009 10:06

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