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Redox state and gender differences in vascular smooth muscle cells

Malorni, Walter and Straface, Elisabetta and Matarrese, Paola and Ascione, Barbara and Coinu, Rita and Canu, Silvia and Galluzzo, Paola and Marino, Maria and Franconi, Flavia (2008) Redox state and gender differences in vascular smooth muscle cells. FEBS Letters, Vol. 582 (5), p. 635-642. ISSN 0014-5793. Article.

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DOI: 10.1016/j.febslet.2008.01.034

Abstract

Vascular smooth muscle cells (VSMC) have been isolated from male and female rat aorta and studied to assess their susceptibility to ultraviolet radiation-induced oxidative stress. Interestingly, a gender difference, in terms of reactive oxygen species production, was detected in both basal and irradiated VSMC. Namely, VSMC from male rats were more susceptible to radiation-induced stress and easier underwent apoptosis in comparison to cells from female rats. Conversely, the latter, in the same experimental conditions, clearly displayed signs of premature senescence. These results indicate that a sort of "gender memory" can be conserved in VMSC in primary culture.

Item Type:Article
ID Code:2025
Status:Published
Refereed:Yes
Uncontrolled Keywords:Reactive oxygen species, vascular smooth muscle cells, gender, senescence, apoptosis
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Elsevier
ISSN:0014-5793
Copyright Holders:© 2008 Federation of European Biochemical Societies
Deposited On:18 Aug 2009 10:06

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