Delehaye, Emilio and Capobianco, Francesco Saverio and Bertetto, Ivano Bruno and Meloni, Francesco (2008) Distortion-product otoacoustic emission: early detection in deferoxamine induced ototoxicity. Auris Nasus Larynx, Vol. 35 (2), p. 198-202. ISSN 0385-8146. Article.
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Objective. Deferoxamine therapy in lifelong transfusion-dependent anaemias, as beta-thalassemia major, is associated with an increased risk of ototoxic changes. With increasing survival rates, prevention and/or early detection of ototoxicity are important for providing management options. The predictive value of pure-tone audiometry in early detection of ototoxicity has been questioned, particularly in the higher frequencies. Otoacoustic emissions appear to be more sensitive to cochlear insult than the conventional pure-tone audiometry. The aim of our study was to compare the efficacy of otoacoustic emissions (distortion-product otoacoustic emissions) with that of pure-tone audiometry as method of audiological monitoring.
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