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Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains

Sotgiu, Stefano and Musumeci, Salvatore and Marconi, Silvia and Gini, Beatrice and Bonetti, Bruno (2008) Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains. Journal of Neuroimmunology, Vol. 197 (1), p. 70-73. ISSN 0165-5728. Article.

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DOI: 10.1016/j.jneuroim.2008.03.021

Abstract

Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown.
The level of plasma Chit activity positively correlates with Alzheimer's disease (AD) and multiple sclerosis (MS). A recent study revealed the presence of potentially detrimental chitin-like substances in AD brain by Calcofluor histochemistry, whilst its search in MS brains has never been described to date. Through a comparative immunohistochemical analysis we confirm the presence of abundant chitin-like deposition in AD brains but fail to demonstrate it in MS brains. Interestingly, co-localization of β-amyloid, Calcofluor and the nuclear marker DAPI was observed. Therefore, Chit production in MS patients is induced by mechanisms other than those operating in AD. Microglia-derived Chit activity in MS may counterbalance the naturally occurring glucosamine aggregation, protecting the brain from the chitin-like substance deposition.

Item Type:Article
ID Code:1975
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chitin, glucosamine, chitotriosidase, multiple sclerosis, Alzheimer's disease, immunohistochemistry
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Elsevier
ISSN:0165-5728
Deposited On:18 Aug 2009 10:06

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