Sechi, Gianpietro and Corda, Davide and Deiana, Giovanni Andrea and Contu, Sabrina and Rosati, Giulio (2003) Carbamazepine, clonazepam and focal reflex proprioceptive seizures. Clinical Neuropharmacology, Vol. 26 (6), p. 327-330. ISSN 0362-5664. Article.
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We studied a 34-year-old man with focal tonic-clonic seizures sometimes elicited by some active postures of the right hand and evolving at times to secondary generalization. Treatment with carbamazepine (CBZ) in combination with parenteral diazepam induced both a dramatic increase of focal reflex proprioceptive seizures and choreoathetoid dyskinesias in the affected hand. CBZ was withdrawn and clonazepam (CZP) given 2 mg daily, with complete relief of seizures and choreoathetoid dyskinesias. CZP had a suppressive effect on seizures for over 15 years, without development of tolerance.
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