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Preparation and characterisation of polymeric films containing propolis

Juliano, Claudia Clelia Assunta and Pala, Caterina Lucia and Cossu, Massimo (2007) Preparation and characterisation of polymeric films containing propolis. Journal of Drug Delivery Science and Technology, Vol. 17 (3), p. 177-180. ISSN 1157-1489. Article.

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Abstract

Propolis is a natural resinous substance, with a high polyphenol content, produced by honeybees and characterized by antimicrobial, anti-inflammatory and antioxidant properties, which make it useful for different therapeutic applications, especially in the stomatological field in the treatment of mild buccal diseases. The aim of this study was to prepare some polymeric film formulations for local delivery of propolis into the oral cavity. For this purpose, a commercial propolis fluid extract and three extracts (dry, ethanolic, glyceric) obtained from raw propolis were previously characterized with regard to their polyphenolic fraction composition and their antimicrobial properties against Candida albicans, Escherichia coli and Staphylococcus aureus strains. Commercial fluid extract, judged the most suitable in terms of polyphenol content and antimicrobial activity, was then incorporated into alginate, alginate-chitosan and agar films, prepared using a casting-solvent evaporation technique, which were finally evaluated in terms of thickness, total polyphenol content, in vitro polyphenol release profiles, swelling behaviour and antimicrobial properties. Our results demonstrate that polymeric films can be proposed as new propolis vehicles in the treatment of dental and buccal diseases.

Item Type:Article
ID Code:1890
Status:Published
Refereed:Yes
Uncontrolled Keywords:Polymeric films, propolis extracts, polyphenols, antimicrobial activity, in vitro release
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Editions de Santé
ISSN:1157-1489
Deposited On:18 Aug 2009 10:06

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