Serra, Pier Andrea and Pluchino, Stefano and Marchetti, Bianca Maria and Desole, Maria Speranza and Miele, Egidio (2008) The MPTP mouse model: cues on DA release and neural stem cell restorative role. Parkinsonism & Related Disorders, Vol. 14 (suppl. 2), S189-S193. ISSN 1353-8020. Article.
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause parkinsonism in humans and this fact is a major incentive for using this toxin as an animal model to study the pathogenesis of Parkinson's disease (PD). Although the monkey MPTP model remains the best, most studies have been performed in mice.
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