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The MPTP mouse model: cues on DA release and neural stem cell restorative role

Serra, Pier Andrea and Pluchino, Stefano and Marchetti, Bianca Maria and Desole, Maria Speranza and Miele, Egidio (2008) The MPTP mouse model: cues on DA release and neural stem cell restorative role. Parkinsonism & Related Disorders, Vol. 14 (suppl. 2), S189-S193. ISSN 1353-8020. Article.

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DOI: 10.1016/j.parkreldis.2008.04.029


1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause parkinsonism in humans and this fact is a major incentive for using this toxin as an animal model to study the pathogenesis of Parkinson's disease (PD). Although the monkey MPTP model remains the best, most studies have been performed in mice.
The so-called acute and sub-acute regimens are commonly used. Both induce tissue striatal dopamine (DA) depletion and nigral neuron death. Tissue striatal DA depletion does not necessarily correlate with impairment of striatal dopaminergic functioning. In freely moving mice, systemic acute or sub-acute MPTP directly induces prolonged release of striatal DA. Such DA release may be considered the first step in MPTP-induced striatal DA depletion. Reportedly, neural stem cells improve symptoms in the MPTP model of PD by interacting with the MPTP-induced pathological nigrostriatal milieu.

Item Type:Article
ID Code:1842
Uncontrolled Keywords:MPTP, neural stem cells, mouse striatum, microdialysis, Parkinson's disease
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Additional Information:This article is based on a presentation given at the LIMPE Seminars 2007 “Experimental Models in Parkinson's Disease” held in September 2007 at the “Porto Conte Ricerche” Congress Center in Alghero, Sardinia, Italy.
Deposited On:18 Aug 2009 10:06

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