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Redox state, cell death and autoimmune diseases: a gender perspective

Ortona, Elena and Margutti, Paola and Matarrese, Paola and Franconi, Flavia and Malorni, Walter (2008) Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmunity Reviews, Vol. 7 (7), p. 579-584. ISSN 1568-9972. Article.

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DOI: 10.1016/j.autrev.2008.06.001

Abstract

Autoimmune disorders, redox balance and gender differences are closely connected. In fact, activation, proliferation and death of cells of different histotype, including blood and vascular cells, are under control of oxidative balance and are key players in autoimmune disease pathogenesis and progression. However, cells from male and female appear characterized by a huge series of differences in terms of reactive oxygen species production and oxidative stress susceptibility. In this review, we briefly summarize the possible implications of the redox state in the onset and progression of autoimmune diseases in a gender perspective.

Item Type:Article
ID Code:1819
Status:Published
Refereed:Yes
Uncontrolled Keywords:Reactive oxygen species, gender, autoimmune diseases, apoptosis
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Elsevier
ISSN:1568-9972
Deposited On:18 Aug 2009 10:06

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