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Cdk9-55: a new player in muscle regeneration

Giacinti, Cristina and Musarò, Antonio and De Falco, Giulia and Jourdan, Isabelle and Molinaro, Mario and Bagella, Luigi Marco and Simone, Cristiano and Giordano, Antonio (2008) Cdk9-55: a new player in muscle regeneration. Journal of Cellular Physiology, Vol. 216 (3), p. 576-582. eISSN 1097-4652. Article.

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DOI: 10.1002/jcp.21361

Abstract

Adult skeletal muscle contains a specialized population of myogenic quiescent stem cells, termed satellite cells, which contribute to repair myofibers after injury. During muscle regeneration, satellite cells exit their normal quiescent state, proliferate, activating MyoD and Myf-5 expression, and finally differentiate and fuse to reconstitute the injured muscle architecture. We have previously reported that cdk9 is required for myogenesis in vitro by activating MyoD-dependent transcription. In myoblasts induced to differentiate, MyoD recruits cdk9 on the chromatin of muscle-specific regulatory regions. This event correlates with chromatin-modifying enzyme recruitment and phosphorylation of cdk9-specific target residues at the carboxyl-terminal domain of RNA polymerase II. Here we report that a second cdk9 isoform, termed cdk9-55, plays a fundamental role in muscle regeneration and differentiation in vivo. This alternative form is specifically induced in injured myofibers and its activity is strictly required for the completion of muscle regeneration process.

Item Type:Article
ID Code:1798
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cdk9-55, regeneration, skeletal muscle
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Wiley-Liss
eISSN:1097-4652
Additional Information:Pubblicato online il 10 giugno 2008.
Deposited On:18 Aug 2009 10:06

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