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Environmental risk factors in multiple sclerosis

Pugliatti, Maura and Harbo, Hanne Flinstad and Holmøy, Trygve and Kampman, Margitta T. and Myhr, Kjell-Morten and Riise, Trond and Wolfson, Christina (2008) Environmental risk factors in multiple sclerosis. Acta Neurologica Scandinavica, Vol. 117 (s188), p. 34-40. eISSN 1600-0404. Article.

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DOI: 10.1111/j.1600-0404.2008.01029.x

Abstract

Objectives – Multiple sclerosis (MS) likely results from an interaction between genetic and exogenous factors. While genetics shapes the overall population MS susceptibility, observed epidemiological patterns strongly suggest a role for the environment in disease initiation and modulation. Results – Findings from studies on seasonality in MS patients' birth, disease onset and exacerbations, as well as apparent temporal trends in incidence and gender ratio support an influential effect of viruses, metabolic and lifestyle factors on MS risk. Epstein–Barr virus, vitamin D status, and smoking are factors that may explain such epidemiological patterns. Conclusions – Further epidemiological investigations are encouraged and opportunities to use data from existing cohort studies as well as the design of new studies should be pursued. In particular, the development of new large multicentre population-based case-control studies which incorporate the study of the role of environment and genetics, including epigenetic mechanisms, in determining MS risk is proposed.

Item Type:Article
ID Code:1753
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, epidemiology, EBV, vitamin D, smoking
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Blackwell Munksgaard
eISSN:1600-0404
Copyright Holders:© 2008 The Authors, Journal compilation © 2008 Blackwell Munksgaard
Additional Information:Presented in: Annual Meeting of the Norwegian Neurological Association, Oslo 26-30 November 2007.
Deposited On:18 Aug 2009 10:06

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