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Sebaceous gland hyperplasia of the foreskin

Ena, Pasquale and Origa, Donatella and Massarelli, Giovannino (2009) Sebaceous gland hyperplasia of the foreskin. Clinical and Experimental Dermatology, Vol. 34 (3), p. 372-374. eISSN 1365-2230. Article.

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DOI: 10.1111/j.1365-2230.2008.02998.x


Two men, aged in their 20s, presented with multiple, soft, rounded papules on the prepuce. The lesions were centrally umbilicated, resembling molluscum contagiosum, but clearly distinct from Tyson's glands. Surface microscopy showed well-defined, milky-white, bag-shaped structures, which under histological examination were found to be sebaceous glands with various features of hyperplasia. A lymphocytic T-cell infiltrate, closely associated with progressive degeneration and destruction of the sebocytes, was visible around the glands. In the differential diagnosis of penile papular lesions, this unusual clinical presentation supported by dermatoscopy is consistent with preputial sebaceous gland hyperplasia. As both patients had a prominent T-cell infiltration, it is possible that under inflammatory stimulation, sebaceous glands undergo hypertrophy and gradual central involution.

Item Type:Article
ID Code:1749
Uncontrolled Keywords:Penile papular lesions, Tyson’s glands, T-cell infiltration, preputial sebaceous gland hyperplasia
Subjects:Area 06 - Scienze mediche > MED/35 Malattie cutanee e veneree
Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:001 Università di Sassari > 03 Istituti > Dermatologia
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:Blackwell / Wiley
Additional Information:Pubblicato online il 9 dicembre 2008.
Deposited On:18 Aug 2009 10:06

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