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Laryngeal true malignant mixed tumor

Stomeo, Franco and Cossu Rocca, Paolo Alessandro and Bozzo, Corrado Pasquale and Bianchini, Chiara and Meloni, Francesco and Pastore, Antonio (2009) Laryngeal true malignant mixed tumor. Head & Neck, Vol. 31 (4), p. 556-560. eISSN 1097-0347. Article.

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Abstract

Background. True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported. Methods and Results. We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery. Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues. Immunohistochemical analyses showed a peculiar expression of myoepithelial markers such as p63 and calponin in the glandular epithelial component, whereas malignant spindle cell proliferation was immunoreactive for calponin and actin. Conclusion. These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell. Despite the unfavorable prognosis that has always been described for these neoplasms, the patient is alive with no evidence of recurrences 5 years after surgery.

Item Type:Article
ID Code:1746
Status:Published
Refereed:Yes
Uncontrolled Keywords:Larynx, neoplasm, mixed tumor, carcinosarcoma, salivary glands tumors
Subjects:Area 06 - Scienze mediche > MED/31 Otorinolaringoiatria
Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:Wiley
eISSN:1097-0347
Additional Information:Pubblicato online il 28 ottobre 2008.
Deposited On:18 Aug 2009 10:06

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