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Addiction and cognitive functions

Spiga, Saturnino and Lintas, Alessandra and Diana, Marco (2008) Addiction and cognitive functions. Annals of the New York Academy of Sciences, Vol. 1139 , p. 299-306. eISSN 1749-6632. Article.

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Drug addiction is a compulsive behavioral abnormality. In spite of pharmacologic and psychosocial treatments to reduce or eliminate drug taking, addiction tends to persist over time. Preclinical and human observations have converged on the hypothesis that addiction represents the pathologic deterioration of neural processes that normally serve affective and cognitive functioning. The major elements of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie enduring changes in a number of forebrain circuits (involving the ventral striatum and prefrontal cortex) that receive input from midbrain dopamine neurons and are involved in affective and cognitive mechanisms, respectively. Here we review progress in identifying crucial elements useful in understanding the pathophysiology of the disease and its pharmacologic treatment. Pharmacologic targeting of K-opiate receptors, with their discrete distribution within the dopaminergic system(s), and thus different actions on dopaminoceptive areas, may provide beneficial effects at the affective and cognitive level.

Item Type:Article
ID Code:1738
Uncontrolled Keywords:Working memory, drug addiction, cognitive functions, methadone, buprenorphine, humans
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Blackwell / Wiley
Copyright Holders:© 2008 New York Academy of Sciences
Additional Information:Paper presentato al First International Drug Abuse Research Society (IDARS) Meeting, a satellite meeting of the International Society for Neurochemistry (ISN) che si è tenuto a Merida, Messico, dal 14 al 17 agosto 2007.
Deposited On:18 Aug 2009 10:05

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