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In vitro study on the anticandidal activity of Melaleuca alternifolia (tea tree) essential oil combined with chitosan

Juliano, Claudia Clelia Assunta and Demurtas, Carla and Piu, Luisella (2008) In vitro study on the anticandidal activity of Melaleuca alternifolia (tea tree) essential oil combined with chitosan. Flavour and Fragrance Journal, Vol. 23 (4), p. 227-231. ISSN 0882-5734. Article.

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DOI: 10.1002/ffj.1871

Abstract

The in vitro activities of commercial Melaleuca alternifolia essential oil (tea tree oil; TTO) and chitosan were investigated against Candida albicans, both alone and in combination, to assess their potential synergistic action; their anticandidal properties were assessed using standard microbiological techniques, such as MIC evaluation and a time-kill test. Our results demonstrated that both TTO and chitosan possess remarkable activity against Candida: TTO inhibited C. albicans at 0.5 % v/v and was able to kill yeast cells in 120 min at 1% and in 300 min at 0.5-0.25%; as far as chitosan was concerned, 0.5 mg/ml were required to inhibit Candida growth in liquid medium, whereas 0.5-2 mg/ml chitosan required 24 h to kill them in the time-kill test; this effect was pH-dependent, being present at pH 5.0 and disappearing at pH 2.0. When TTO and chitosan were tested together, the polymer reduced the MIC of TTO but did not enhance the activity of the oil as evaluated in the "time-kill" test.

Item Type:Article
ID Code:1736
Status:Published
Refereed:Yes
Uncontrolled Keywords:Tea tree oil, Chitosan, Candida albicans, antifungal activity
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Wiley
ISSN:0882-5734
Deposited On:18 Aug 2009 10:05

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