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Subcutaneous nadroparin calcium in the treatment of retinal vein occlusion

Pinna, Antonio <1963- > and Simula, P. and Salvo, Marco Michele and Devilla, L. and Zinellu, Angelo and Carta, Arturo (2008) Subcutaneous nadroparin calcium in the treatment of retinal vein occlusion. Acta Ophthalmologica, Vol. 86 (s243), 0-0. eISSN 1755-3768. Article.

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DOI: 10.1111/j.1755-3768.2008.638.x

Abstract

Purpose: To date, no systemic intervention has been demonstrated to favorably affect the natural history of retinal vein occlusion (RVO). The purpose of this study was to evaluate the efficacy of nadroparin calcium in the treatment of RVO. Methods: 13 patients with acute RVO (i.d. within a week of onset) were treated with subcutaneous injections of nadroparin calcium for 2 months. The same dose used for the treatment of deep venous thrombosis (200UI/kg/die) was given. Best corrected visual acuity (BCVA) in the affected eye was measured at baseline and after 3 months. In addition, macular thickness was measured by Stratus OCT (Carl Zeiss Meditec, USA) at baseline and after 3 months. Results: Mean visual acuity was 0.39±0.33 at baseline and 0.70±0.32 after 3 months; differences were statistically significant (P=0.024). Macular thickness was measured in 8 patients; mean thickness was 510±239 μm at baseline and 331±190 μm after 3 months; differences were not statistically significant (P=0.12). After 3 months, fluorescein angiography disclosed no signs of retinal ischemia in all cases. Conclusion: This preliminary study suggest that subcutaneous nadroparin calcium may be effective in the treatment of RVO. Larger long-term studies are warranted to confirm this results.

Item Type:Article
ID Code:1719
Status:Published
Refereed:Yes
Uncontrolled Keywords:Retinal Vein Occlusion (RVO), nadroparin calcium, Best Corrected Visual Acuity (BCVA)
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Publisher:Blackwell / Wiley
eISSN:1755-3768
Copyright Holders:Journal compilation © 2009 Acta Ophthalmologica
Additional Information:Abstract from the 2008 European Association for Vision and Eye Research Conference
Deposited On:18 Aug 2009 10:05

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