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Effect of cryo-preservation on the response of different biological systems to gamma-ray exposure: a feasibility study

Bottigli, Ubaldo and Brunetti, Antonio and Carpinelli, Massimo and Diaz, Nicia and Fiori, Pier Luigi and Golosio, Bruno and Masala, Giovanni Luca Christian and Oliva, Piernicola and Randaccio, Paolo and Santona, S. and Zamai, Loris and Centis, F. and Valentini, M. and Cesarini, Werther and Canonico, Barbara and Grianti, Francesco and Balata, Marco and Nisi, Stefano and Laubenstein, Matthias and Papa, Stefano and Bedogni, Roberto and Esposito, Adolfo and Cherubini, Roberto and De Nadal, V. and Gerardi, Silvia (2008) Effect of cryo-preservation on the response of different biological systems to gamma-ray exposure: a feasibility study. Il Nuovo cimento. C, Vol. 31 C (1), p. 11-20. eISSN 1826-9885. Article.

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DOI: 10.1393/ncc/i2008-10276-6

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Cryopreservation of cells, tissues or organisms (i.e. the storage at liquid-nitrogen or nitrogen vapour temperature) offers the most secure form of preservation, allowing cells to be maintained unaltered for a long time and preventing them from ageing. On the other hand, the multi-year exposure of cryo-preserved cells (like: stem and germ cells) to the environmental gamma-ray background might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms, and contribute to cancer or non-cancer pathology risk assessment when such cells should be transplanted in individuals. To investigate the effect of the cryopreservation on the cell response to radiation exposures, the response of different biological systems (bacteria and mammalian cells) to gamma-rays has been evaluated after irradiation in cryo-preserved and culture conditions, as a function of dose and doserate, in terms of a variety of cellular and molecular end-points.

Item Type:Article
ID Code:1691
Uncontrolled Keywords:Gamma-ray effects, ionizing radiation, dosimetry/exposure assessment
Subjects:Area 02 - Scienze fisiche > FIS/07 Fisica applicata (a beni culturali, ambientali, biologia e medicina)
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Matematica e fisica
Publisher:Società Italiana di Fisica
Deposited On:18 Aug 2009 10:05

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