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Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry

Boatto, Gianpiero and Nieddu, Maria and Pirisi, Maria Antonietta and Dessì, Giuseppina (2007) Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. Rapid Communications in Mass Spectrometry, Vol. 21 (22), p. 3716-3720. eISSN 1097-0231. Article.

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DOI: 10.1002/rcm.3273

Abstract

A simple method for the simultaneous identification and quantification of four 2,5-methylenedioxy derivatives of 4-thioamphetamine (ALEPH series) in plasma samples was developed. The method consists of solid-phase extraction (SPE) using a Bond Elut C18 cartridge and capillary electrophoresis coupled with electrospray ionisation mass spectrometry (CE/ESI-MS). The SPE method used required only simple steps and provided a clean extract from which identification of each drug was feasible, even at low concentrations. The method was validated according to international guidelines. The calibration curves were linear over the concentration range of 50 to 1000 ng/mL for all drugs with correlation coefficients that exceeded 0.998. The lower limits of detection of the drugs were 23–43 ng/mL. The absolute recoveries for the drugs were 64–92% and 75–96% at concentrations of 100 and 500 ng/mL, respectively. The validation data (precision, accuracy, and recovery) show the reproducibility and selectivity of the method. This clean and simple method allows the routine detection of designer drugs such as thioamphetamines which may become a serious problem in the control of illegal drugs.

Item Type:Article
ID Code:1618
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thioamphetamine, capillary electrophoresis
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Wiley
eISSN:1097-0231
Deposited On:18 Aug 2009 10:05

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