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Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia

Budroni, Mario and Cesaraccio, Rosaria and Coviello, Vincenzo and Sechi, Ornelia and Pirino, Daniela and Cossu, Antonio and Tanda, Francesco and Pisano, Marina and Palomba, Grazia and Palmieri, Giuseppe (2009) Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia. BMC Cancer, Vol. 9 (62), p. 1-7. ISSN 1471-2407. Article.

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DOI: 10.1186/1471-2407-9-62

Abstract

Background: Germline mutations in BRCA1 or BRCA2 genes have been demonstrated to increase the risk of developing breast cancer. Conversely, the impact of BRCA mutations on prognosis and survival of breast cancer patients is still debated. In this study, we investigated the role of such mutations on breast cancer-specific survival among patients from North Sardinia. Methods: Among incident cases during the period 1997–2002, a total of 512 breast cancer patients gave their consent to undergo BRCA mutation screening by DHPLC analysis and automated DNA sequencing. The Hakulinen, Kaplan-Meier, and Cox regression methods were used for both relative survival assessment and statistical analysis. Results: In our series, patients carrying a germline mutation in coding regions and splice boundaries of BRCA1 and BRCA2 genes were 48/512 (9%). Effect on overall survival was evaluated taking into consideration BRCA2 carriers, who represented the vast majority (44/48; 92%) of mutation-positive patients. A lower breast cancer-specific overall survival rate was observed in BRCA2 mutation carriers after the first two years from diagnosis. However, survival rates were similar in both groups after five years from diagnosis. No significant difference was found for age of onset, disease stage, and primary tumour histopathology between the two subsets. Conclusion: In Sardinian breast cancer population, BRCA2 was the most affected gene and the effects of BRCA2 germline mutations on patients' survival were demonstrated to vary within the first two years from diagnosis. After a longer follow-up observation, breast cancer-specific rates of death were instead similar for BRCA2 mutation carriers and non-carriers.

Item Type:Article
ID Code:1610
Status:Published
Refereed:Yes
Uncontrolled Keywords:BRCA2, cancer, Sardinia
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari > Unità genetica dei tumori
001 Università di Sassari > 03 Istituti > Anatomia patologica
002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Centro multizonale di osservazione epidemiologica > Registro tumori di Sassari
Publisher:BioMed Central
ISSN:1471-2407
Deposited On:18 Aug 2009 10:05

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