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Issues affecting molecular staging in the management of patients with melanoma

Palmieri, Giuseppe and Casula, Milena and Sini, Maria Cristina and Ascierto, Paolo Antonio and Cossu, Antonio (2007) Issues affecting molecular staging in the management of patients with melanoma. Journal of Cellular and Molecular Medicine, Vol. 11 (5), p. 1052-1068. eISSN 1582-4934. Article.

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DOI: 10.1111/j.1582-4934.2007.00091.x

Abstract

Prediction of metastatic potential remains one of the main goals to be pursued in order to better assess the risk subgroups of patients with melanoma. Detection of occult melanoma cells in peripheral blood (circulating metastatic cells [CMC]) or in sentinel lymph nodes (sentinel node metastatic cells [SNMC]), could significantly contribute to better predict survival in melanoma patients. An overview of the numerous published studies indicate the existence of several drawbacks about either the reliability of the approaches for identification of occult melanoma cells or the clinical value of CMC and SNMC as prognostic factors among melanoma patients. In this sense, characterization of the molecular mechanisms involved in development and progression of melanoma (referred to as melanomagenesis) could contribute to better classify the different subsets of melanoma patients. Increasing evidence suggest that melanoma develops as a result of accumulated abnormalities in genetic pathways within the melanocytic lineage. The different molecular mechanisms may have separate roles or cooperate during all evolutionary phases of melanocytic tumourigenesis, generating different subsets of melanoma patients with distinct aggressiveness, clinical behaviour, and response to therapy. All these features associated with either the dissemination of occult metastatic cells or the melanomagenesis might be useful to adequately manage the melanoma patients with different prognosis as well as to better address the different melanoma subsets toward more appropriate therapeutic approaches.

Item Type:Article
ID Code:1604
Status:Published
Refereed:Yes
Uncontrolled Keywords:Melanoma, occult micrometastasis, RT-PCR assay, pathogenetic mechanism, molecular profile, prognosis
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Servizio di anatomia patologica
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Blackwell / Wiley
eISSN:1582-4934
Copyright Holders:© 2007 The Authors, Journal compilation © 2007 Foundation for Cellular and Molecular Medicine/Blackwell
Deposited On:18 Aug 2009 10:05

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