Cottoni, Francesca Maria Giovanna and Ceccarelli, Simona and Masala, Maria Vittoria and Montesu, Maria Antonia and Satta, Rosanna Rita and Pirodda, Caterina and Rotolo, Sabrina and Frati, Luigi and Marchese, Cinzia and Angeloni, Antonio (2009) Overexpression of the fibroblast growth factor receptor 2-IIIc in Kaposi's sarcoma. Journal of Dermatological Science, Vol. 53 (1), p. 65-68. ISSN 0923-1811. Article.
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Kaposi's sarcoma (KS) is a neoplastic disorder characterized by a highly vascularized lesion with bundles of spindle-shaped cells, pathognomonic of the disease, infiltrated by mononuclear inflammatory and plasma cells. The KS lesion presents as a patch/plaque, which eventually develops into a nodular tumor. Thus far, the mechanisms involved in the etiopathogenesis of KS are not completely understood. Kaposi's Sarcoma-associated Herpesvirus (KSHV) infection is present in all KS cases. However, KSHV is not sufficient for the development of the disease and other factors are certainly involved. Alterations in the expression of cytokines, growth factors and relative receptors have been analyzed over the years.
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