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Coordination ability of insect kinin analogs

Lodyga-Chruscinska, Elzbieta and Oldziej, Stanislaw and Sanna, Daniele and Micera, Giovanni and Chruscinski, Longin and Kaczmarek, Krzysztof and Nachman, Ronald J. and Zabrocki, Janusz and Sykula, Anna (2009) Coordination ability of insect kinin analogs. Polyhedron, Vol. 28 (3), p. 485-492. ISSN 0277-5387. Article.

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DOI: 10.1016/j.poly.2008.11.051


Spectroscopic data, including electronic absorption, CD and EPR results, as well as theoretical calculations have shown that the insertion of 4-aminopyroglutamate, a novel cis-peptide bond mimic, in the insect kinin peptide leads to an effective ligand towards Cu(II) ions at basic pH ranges. The 4-aminopyroglutamate motif induces a specific peptide conformation which favors the formation of one or two five-membered chelating rings stabilizing a bent structure, with the coordination of 3N-type or 4N-type in the metallopeptide molecule involving in metal bonding C-terminal of modified peptide. It is worth noting that the copper(II) bonding does not undergo hydrolysis even at a very high pH range.

Item Type:Article
ID Code:1523
Uncontrolled Keywords:Metallopeptides, complex formation, 4-aminopyroglutamate motif
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Pergamon / Elsevier
Copyright Holders:© 2008 Elsevier
Deposited On:18 Aug 2009 10:05

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