Peana, Alessandra Tiziana and Assaretti, Anna Rita and Muggironi, Giulia and Enrico, Paolo and Diana, Marco (2009) Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine. Alcoholism: Clinical and Experimental Research, Vol. 33 (1), p. 43-48. eISSN 1530-0277. Article.
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Background: Experimental evidences suggest that acetaldehyde (ACD) contributes to the positive motivational properties of ethanol (EtOH) as assessed by the place conditioning paradigm; indeed, we found that by reducing ACD production and/or by using ACD-sequestrating agents, EtOH is deprived from its motivational properties. Thiol products, such as the amino acid cysteine, are known to be effective ACD-sequestering agents. Cysteine is able to covalently bind ACD thereby forming a stable, nontoxic 2-methyl-thiazolidine-4-carboxylic acid compound. Thus, we treated rats with L-cysteine before intragastric administration of EtOH or ACD.
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