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Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine

Peana, Alessandra Tiziana and Assaretti, Anna Rita and Muggironi, Giulia and Enrico, Paolo and Diana, Marco (2009) Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine. Alcoholism: Clinical and Experimental Research, Vol. 33 (1), p. 43-48. eISSN 1530-0277. Article.

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DOI: 10.1111/j.1530-0277.2008.00809.x

Abstract

Background: Experimental evidences suggest that acetaldehyde (ACD) contributes to the positive motivational properties of ethanol (EtOH) as assessed by the place conditioning paradigm; indeed, we found that by reducing ACD production and/or by using ACD-sequestrating agents, EtOH is deprived from its motivational properties. Thiol products, such as the amino acid cysteine, are known to be effective ACD-sequestering agents. Cysteine is able to covalently bind ACD thereby forming a stable, nontoxic 2-methyl-thiazolidine-4-carboxylic acid compound. Thus, we treated rats with L-cysteine before intragastric administration of EtOH or ACD.
Methods: Male Wistar rats were pretreated intraperitoneally with saline or L-cysteine (10, 20, or 30 mg/kg), before intragastric administration of saline, EtOH (1 g/kg), or ACD (20 mg/kg). The specificity of l-cysteine effect was addressed using morphine-induced conditioned place preference (cpp) (2.5 mg/kg, i.p.).
Results: L-cysteine dose-dependently prevented both EtOH and ACD-induced cpp but did not interfere with morphine-induced cpp, suggesting that L-cysteine specifically modulates the motivational properties of EtOH.
Conclusion: The present results further underscore the role of EtOH-derived ACD in EtOH-induced motivational properties. L-cysteine, by binding EtOH-derived ACD, would deprive it of its rewarding properties and reduce its abuse liability.

Item Type:Article
ID Code:1514
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ethanol, acetaldehyde, conditioned place preference, L-cysteine, rat, alcohol dependence
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Blackwell
eISSN:1530-0277
Copyright Holders:© 2008 Research Society on Alcoholism
Deposited On:18 Aug 2009 10:05

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