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Are the basal ganglia involved in language comprehension? A neurophysiological attempt

Paulus, Kai Stephan and Sechi, Gianpietro and Galistu, Paola and Canu, Edoardo Domenico Giorgio and Magnano, Immacolata and Agnetti, Virgilio and Aiello, Isidoro Cesare Giuseppe (2005) Are the basal ganglia involved in language comprehension? A neurophysiological attempt. Parkinsonism & Related Disorders, Vol. 11 (Suppl. 2), p. 243-244. ISSN 1353-8020. Article.

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DOI: 10.1016/S1353-8020(05)80128-2

Abstract

Deficits of language comprehension in non-demented patients with Parkinson's disease (PD) have been observed. These alterations concern verbal fluency, the semantic domain and the cognitive-linguistic flexibility. An involvement of the nucleus candatus in linguistic comprehension has been hypothesized. The event-related potentials (ERPs) represent an electrophysiological tool for studying the global cognitive state (P300) and linguistic functions of semantic and syntactic postlexical integration (N400 and P600, respectively). To evaluate language comprehension in patients with PD by means of ERPs and neuropsychological evaluation and to compare these results with those obtained in a case of restless legs syndrome (RLS) secondary to ischemic stroke in the basal ganglia region.

Item Type:Article
ID Code:1493
Status:Published
Refereed:Yes
Uncontrolled Keywords:Language comprehension deficit, Parkinson's disease, neuropsychological evaluation
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:Elsevier
ISSN:1353-8020
Additional Information:Poster presented at the 16. International Congress on Parkinson's Disease and Related Disorders. Berlin, Germany, June 5-9, 2005.
Deposited On:18 Aug 2009 10:05

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