Abstract

Idiopatic Parkinson's disease (IPD) is the most common neurodegenerative movement disorder. Others closely related parkinsonian disorders, like corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), share many clinical features, such as rapid disease progression, poor levodopa response, eye movement abnormalities, cognitive impairment, apraxia, pyramidal signs, and dystonia. These similarities often cause difficulty in clinical differentiation, especially in their early course. Traditional neuroimaging methods, such as MRI, SPET, and PET, may improve diagnostic accuracy, but not in early stages or even in the preclinical stage of the nigrostriatal degeneration, except maybe PET. However, these techniques are expensive, and largely unavailable for routine diagnostic workup.

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