Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies

Sechi, Gianpietro and Agnetti, Virgilio and Masuri, Raffaella and Deiana, Giovanni Andrea and Pugliatti, Maura and Paulus, Kai Stephan and Rosati, Giulio (2000) Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 24 (6), p. 1043-1051. ISSN 0278-5846. Article.

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DOI: 10.1016/S0278-5846(00)00123-8

Abstract

1. 1. Conflicting reports are available regarding the sensitivity of patients with Dementia with Lewy bodies (DLB) to risperidone.
2. 2. The authors studied a rare familial case of probable DLB, who developed a documented episode of neuroleptic malignant syndrome (NMS) following the exposure to risperidone. Previously, the patient had had an episode of NMS on trifluoperazine.
3. 3. The discontinuance of risperidone, in combination with a mild increase of dopaminergic therapy, led to a complete recovery in few days.
4. 4. In patients with DLB, a continued vigilance for extrapyramidal side effects, including NMS, would be advisable during the use of risperidone.

Item Type:	Article
ID Code:	1487
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Familial dementia with Lewy bodies, neuroleptic malignant syndrome, risperidone
Subjects:	Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:	001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:	Elsevier Science
ISSN:	0278-5846
Deposited On:	18 Aug 2009 10:05

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