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Reduced microbicidal and anti-tumour activities of human monocytes after ingestion of Plasmodium falciparum-infected red blood cells

Fiori, Pier Luigi and Rappelli, Paola and Mirkarimi, S. N. and Ginsburg, Hagai and Cappuccinelli, Pietro Antonio and Turrini, Francesco Michelangelo (1993) Reduced microbicidal and anti-tumour activities of human monocytes after ingestion of Plasmodium falciparum-infected red blood cells. Parassite Immunology, Vol. 15 (12), p. 647-655. eISSN 1365-3024. Article.

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DOI: 10.1111/j.1365-3024.1993.tb00579.x

Abstract

Oxidatively stressed red blood cells (RBC) and Plasmodium falciparum-infected RBC (PRBC) are avidly phago-cytosed by human peripheral monocytes. Following the ingestion of PRBC the monocytes' ability to phagocytose PRBC and to generate aggressive oxidative compounds is severely impaired. In the present work the microbicidal and anti-tumour capacities of monocytes fed with diamide-treated RBC and PRBC harbouring mature (trophozoite) parasites have been investigated. The capacity of the latter, but not of the former, to phagocytose Escherichia coli and Staphylococcus aureus and to kill them, as well as ingested Candida albicans cells intracellularly, was found to be markedly impaired. Monocytes that have ingested PRBC had a significantly reduced cytostatic and cytolytic activities against a lymphoblastic tumour cell line. Monocytesfed with oxidatively stressed RBC had normal or sometimes even greater anti-tumour activities. Monocytes that have ingested PRBC showed a reduced capability to produce superoxide following stimulation with phorbol ester. Such impairment in monocyte functions may explain the reduced antibacterial and anti-tumour activities of monocytes in malaria patients, and could be consequential to their ability to resist bacterial infections and to provide means for the control of tumour development in those patients.

Item Type:Article
ID Code:1452
Status:Published
Refereed:Yes
Uncontrolled Keywords:Plasmodium falciparum, Escherichia coli, Staphylococcus aureus, Candida albicans, monocyte, phagocytosis, cancer cells, malaria
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Blackwell / Wiley
eISSN:1365-3024
Additional Information:Pubblicato online il 9 ottobre 2007.
Deposited On:18 Aug 2009 10:05

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