Potentiometric and spectroscopic studies on the copper(II) complexes of peptide hormones containing disulfide bridges

Danyi, Péter and Várnagy, Katalin and Sóvágó, Imre and Schön, István and Sanna, Daniele and Micera, Giovanni (1995) Potentiometric and spectroscopic studies on the copper(II) complexes of peptide hormones containing disulfide bridges. Journal of Inorganic Biochemistry, Vol. 60 (1), p. 69-78. ISSN 0162-0134. Article.

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DOI: 10.1016/0162-0134(95)00003-7

Abstract

Copper(II) complexes of oxytocin, 4-Glu-oxytocin, 5-Asp-oxytocin, and GlyGlyGly-Lys⁸-vasopressin were studied by potentiometric, EPR, and UV-visible spectroscopic methods. The formation of 4N-coordinated complexes was characteristic of all ligands. This type of coordination is especially favored for oxytocin due to the specific conformation of the ring coupled by the disulfide bridge. The coordination of the γ-carboxylate group of 4-Glu-oxytocin and a disulfide sulfur atom of GlyGlyGly-Lys⁸-vasopressin was reported to occur in the 2N-complexes over medium pH range.

Item Type:	Article
ID Code:	1449
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Copper(II) complexes, peptide hormones, disulfide bridges, spectroscopy
Subjects:	Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:	Elsevier Science
ISSN:	0162-0134
Deposited On:	18 Aug 2009 10:05

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