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Potentiometric and spectroscopic studies on the copper(II) complexes formed by oligopeptides containing histidine with a protection at the terminal amino group

Sanna, Daniele and Agoston, Csaba Gábor and Sóvágó, Imre and Micera, Giovanni (2001) Potentiometric and spectroscopic studies on the copper(II) complexes formed by oligopeptides containing histidine with a protection at the terminal amino group. Polyhedron, Vol. 20 (9-10), p. 937-947. ISSN 0277-5387. Article.

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DOI: 10.1016/S0277-5387(01)00747-1

Abstract

Copper(II) complexes of oligopeptides with protected amino groups (Z-His-OH, Z-HisGly-OH, Z-GlyHis-OH and Z-GlyGlyHis-OH) were studied by potentiometric and spectroscopic methods. The involvement of the imidazole nitrogen in metal binding was proved in slightly acidic media. The deprotonation and coordination of the amide nitrogen atoms from the carbamate or peptide CONH--- moieties occurred around pH 7, which resulted in the formation of 2N (Z-His-OH and Z-HisGly-OH), 3N (Z-GlyHis-OH) and 4N (Z-GlyGlyHis-OH) complexes supporting the anchoring ability of the imidazole rings. Ternary complexes with 2,2′-bipyridine, L -histidine or glycine (B) were also studied. The major species contained chelated B ligands, whereas the oligopeptide behaved as N-monodentate or 2N-bidentate. The outstanding stability of the 4N complex of Z-GlyGlyHis-OH ([CuH−3A]2−) ruled out mixed complex formation at high pH values.

Item Type:Article
ID Code:1405
Status:Published
Refereed:Yes
Uncontrolled Keywords:Copper(II) complexes, oligopeptides, imidazole, potentiometry, EPR
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Pergamon / Elsevier
ISSN:0277-5387
Copyright Holders:© 2001 Elsevier Science
Additional Information:Pubblicato online il 31 maggio 2001.
Deposited On:18 Aug 2009 10:05

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