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Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis

Di Bona, Danilo and Vasto, Sonya and Capurso, Cristiano and Christiansen, Lene and Deiana, Luca and Franceschi, Claudio and Hurme, Mikko and Moccheggiani, Eugenio and Rea, Maeve and Lio, Domenico and Candore, Giuseppina and Caruso, Calogero (2009) Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Research Reviews, Vol. 8 (1), p. 36-42. ISSN 1568-1637. Article.

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DOI: 10.1016/j.arr.2008.09.001

Abstract

Several studies have assessed changes in frequency of −174 interleukin (IL)-6 single nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related diseases, then there should be reduction, in the oldest old, of the frequency of homozgyous GG subjects, who produce higher IL-6 levels. However, discordant results have been obtained. To explore the relationship between this polymorphism and longevity, we analyzed individual data on long-living subjects and controls from eight case–control studies conducted in Europeans, using meta-analysis. There was no significant difference in the IL-6 genotype between the oldest old and controls (Odds Ratio [OR] = 0.96; 95% C.I.: 0.77–1.20; p = 0.71), but there was significant between-study heterogeneity (I2 = 55.5%). In a subgroup analyses when male centenarians from the three Italian studies were included, the frequency of the IL-6 −174 GG genotype was significantly lower than the other genotypes (OR = 0.49; 95% C.I.: 0.31–0.80; p = 0.004), with no evidence of heterogeneity (I2 = 0%). Our data supports a negative association between the GG genotype of IL-6 SNP and longevity in Italian centenarians, with males who carry the genotype being two times less likely to reach extreme old age compared with subjects carrying CC or CG genotypes. These findings were not replicated in other European groups suggesting a possible interaction between genetics, sex and environment in reaching longevity.

Item Type:Article
ID Code:1375
Status:Published
Refereed:Yes
Uncontrolled Keywords:Longevity, IL-6, polymorphisms, meta-analysis
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Elsevier Ireland
ISSN:1568-1637
Deposited On:18 Aug 2009 10:05

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