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Estimating clinical chemistry reference values based on an existing data set of unselected animals

Dimauro, Corrado and Bonelli, Piero and Nicolussi, Paola and Rassu, Salvatore Pier Giacomo and Cappio Borlino, Aldo and Pulina, Giuseppe (2008) Estimating clinical chemistry reference values based on an existing data set of unselected animals. The Veterinary Journal, Vol. 178 (2), p. 278-281. ISSN 1090-0233. Article.

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DOI: 10.1016/j.tvjl.2007.08.002

Abstract

In an attempt to standardise the determination of biological reference values, the International Federation of Clinical Chemistry (IFCC) has published a series of recommendations on developing reference intervals. The IFCC recommends the use of an a priori sampling of at least 120 healthy individuals. However, such a high number of samples and laboratory analysis is expensive, time-consuming and not always feasible, especially in veterinary medicine. In this paper, an alternative (a posteriori) method is described and is used to determine reference intervals for biochemical parameters of farm animals using an existing laboratory data set. The method used was based on the detection and removal of outliers to obtain a large sample of animals likely to be healthy from the existing data set. This allowed the estimation of reliable reference intervals for biochemical parameters in Sarda dairy sheep. This method may also be useful for the determination of reference intervals for different species, ages and gender.

Item Type:Article
ID Code:1348
Status:Published
Refereed:Yes
Uncontrolled Keywords:Reference values, clinical chemistry, outliers, sheep
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/19 Zootecnica speciale
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze zootecniche
002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
Publisher:Elsevier
ISSN:1090-0233
Copyright Holders:© 2007 Elsevier
Deposited On:18 Aug 2009 10:04

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