UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Glatiramer acetate reduces lymphocyte proliferation and enhances IL-5 and IL-13 production through modulation of monocyte-derived dendritic cells in multiple sclerosis

Sanna, Alessandra and Fois, Maria Laura and Arru, Giannina and Huang, Yu-Min and Link, Hans and Pugliatti, Maura and Rosati, Giulio and Sotgiu, Stefano (2006) Glatiramer acetate reduces lymphocyte proliferation and enhances IL-5 and IL-13 production through modulation of monocyte-derived dendritic cells in multiple sclerosis. Clinical and Experimental Immunology, Vol. 143 (2), p. 357-362. eISSN 1365-2249. Article.

Full text not available from this repository.

DOI: 10.1111/j.1365-2249.2006.02997.x

Abstract

Dendritic cells (DC), as the most effective antigen presenting cells, are protagonists of the complex immune network involved in multiple sclerosis (MS) lesion formation. Glatiramer acetate (GA), a synthetic random copolymer, is thought to exert its therapeutical effect in MS by favouring both Th2 cell development and IL-10 production from peripheral lymphocytes as well as by systemically affecting the antigen presenting cells. In the present study we further analysed the mechanisms of action of GA by using an autologous DClymphocytes (Ly) coculture system from 11 MS patients and 12 matched healthy controls (HC). We found that, in MS patients, pretreatment with GA significantly decreases the in vitro proliferative effect of DC on lymphocytes as compared to HC and to unpulsed or myelin basic protein (MBP)-pulsed DC from MS patients ( P < 0·05). In addition, GA-treated DC from both MS patients and HC significantly increase the lymphocyte production of IL-5 and IL-13 as compared to MBP-treated DC ( P < 0·05). In conclusion our in vitro study may provide new therapeutical mechanisms of GA on lymphocytes, antiproliferative and Th2-favouring effects, which are mediated by monocytederived DC.

Item Type:Article
ID Code:1332
Status:Published
Refereed:Yes
Uncontrolled Keywords:Glatiramer acetate, multiple sclerosis, dendritic cells, lymphocytes, cytokines
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:British Society for Immunology
eISSN:1365-2249
Deposited On:18 Aug 2009 10:04

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page