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Epileptic seizures after treatment with thiocolchicoside

De Riu, Pier Luigi and Rosati, Giulio and Sotgiu, Stefano and Sechi, Gianpietro (2001) Epileptic seizures after treatment with thiocolchicoside. Epilepsia, Vol. 42 (8), p. 1084-1086. eISSN 1528-1167. Article.

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DOI: 10.1046/j.1528-1157.2001.0420081084.x


Purpose: To report the occurrence of epileptic seizures in humans, closely related to the use of the centrally acting muscle relaxant thiocolchicoside. Methods: Description of three case histories. Results: Two patients, affected with complex-partial seizures, sometimes secondarily generalized, receiving antiepileptic therapy, were seizure free for 7 and 9 years, respectively. They had the reappearance of tonic–clonic seizures few days after the continued use of thiocolchicoside, at a cumulative dose of the drug of 52 mg and 76 mg, respectively. The third patient was brain damaged and without a history of seizures. He had a sudden, convulsive seizure a few minutes after 4 mg intramuscular thiocolchicoside. Conclusions: Our case histories indicate that thiocolchicoside has a powerful epileptogenic activity. This drug should be avoided in patients with epilepsy or acute brain injury and possible disruption of the blood–brain barrier.

Item Type:Article
ID Code:1328
Uncontrolled Keywords:Thiocolchicoside therapy, epileptic seizures, epileptogenic activity
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:Blackwell / Wiley
Copyright Holders:© International League Against Epilepsy
Additional Information:Pubblicato online il 20 dicembre 2001.
Deposited On:18 Aug 2009 10:04

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