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First direct detection of rickettsial pathogens and a new rickettsia, 'Candidatus Rickettsia barbariae', in ticks from Sardinia, Italy

Mura, Antonio and Masala, Giovanna and Tola, Sebastiana and Satta, Giuseppe and Fois, Francesco and Piras, Pierpaola and Rolain, Jean-Marc and Raoult, Didier and Parola, Philippe (2008) First direct detection of rickettsial pathogens and a new rickettsia, 'Candidatus Rickettsia barbariae', in ticks from Sardinia, Italy. Clinical Microbiology and Infection, Vol. 14 (11), p. 1028-1003. eISSN 1469-0691. Article.

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DOI: 10.1111/j.1469-0691.2008.02082.x

Abstract

The present study evaluated the molecular detection and identification of Rickettsia species in 83 ticks collected in Sardinia, Italy. Fifteen ticks were PCR-positive using gltA-specific and ompA-specific primers, leading to the identification of Rickettsia aeschlimannii in Hyalomma marginatum marginatum, R. massiliae in Rhipicephalus turanicus and in Rhipicephalus sanguineus, and a new rickettsia, previously referred to as PoTiRb169 in Portugal, in four Rhipicephalus turanicus. This new species was further characterized by amplification and sequencing of three additional genes (ompB, sca4 and rrs). Using the current criteria to name a rickettsia, this uncultivated rickettsia can be given a Candidatus status, and we propose to call it 'Candidatus Rickettsia barbariae'. The detection of three tick-borne rickettsiae in Sardinia raises the possibility that many cases of spotted fever considered by clinicians and health authorities as Mediterranean spotted fever due to R. conorii could, in fact, be due to other rickettsiae, including those found in this study. Analysing skin biopsies of inoculation eschars in patients with spotted fever would be, together with continuing entomological surveys, the best way to increase our knowledge of tick-borne rickettsioses in Sardinia and more generally in the Mediterranean basin.

Item Type:Article
ID Code:1324
Status:Published
Refereed:Yes
Uncontrolled Keywords:Rickettsia, spotted fever, ticks, Italy, Sardinia
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/05 Malattie infettive degli animali domestici
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
Publisher:Blackwell / Wiley
eISSN:1469-0691
Copyright Holders:© 2008 The Authors, Journal Compilation © 2008 European Society of Clinical Microbiology and Infectious Diseases
Deposited On:18 Aug 2009 10:04

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